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The emergence of Cryptococcus gattiily regarded as a predominantly tropical pathogen, in the temperate climate of the North American Pacific Northwest PNW in prompted several questions. The most prevalent among these was the timing of the introduction of this pathogen to this novel environment.

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Here, we infer tip-dated timing estimates for the three clonal C. We estimated the nucleotide substitution rate for each lineage 1. The clonal nature of the PNW C. Our suggest that the mean time to most recent common ancestor for all three sublineages occurred within the last 60 to years. While the cause of C. These studies lead to the general conclusion that the subtypes identified likely emerged out of Brazil.

Here, we conducted genomic dating analyses to determine the ages of the various lineages seen in the PNW and propose hypothetical causes for the dispersal events.

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Bayesian evolutionary analysis strongly suggests that these independent fungal populations in the PNW are all 60 to years old, providing a timing that is subsequent to the opening of the Panama Canal, which allowed for more direct shipping between Brazil and the western North American coastline, a possible driving event for these fungal translocation events. Keywords: Cryptococcus; genomics; molecular epidemiology; mycology.

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RSS Link Copy. Full text links Cite Display options Display options. Abstract The emergence of Cryptococcus gattiily regarded as a predominantly tropical pathogen, in the temperate climate of the North American Pacific Northwest PNW in prompted several questions. Figures FIG 1 Maximum-likelihood phylogeny and geographic locations…. Geographic representations of the three PNW clones are a generalized depiction of the primary impact region of each in the PNW. FIG 2 Bayesian phylogenetic analyses of C. BEAST 1.

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Bayesian phylogenetic analyses of C. The tips of the branches correspond to the year of sampling. Adapted from reference with permission from National Geographic. See this image and copyright information in PMC. Origin of the West Nile virus responsible for an outbreak of encephalitis in the Northeastern United States.

Science — Perspectives on West Africa Ebola virus disease outbreak, — Emerg Infect Dis — Biological and historical overview of Zika virus.

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J Virol —8. PLoS One e Hantaviruses in the Americas and their role as emerging pathogens. Viruses — Copy Download.

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